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University of Iowa College of Public Health

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You are here: Home / Team Showcase / Anumantha Kanthasamy, MPhil, PhD

Anumantha Kanthasamy, MPhil, PhD

May 20, 2021 By

Center Affiliation and Expertise: Systemic and Redox Toxicology Thematic Area, Inflammation and Innate Immunity Thematic Area

 

Dr. Kanthasamy’s research team has been at the forefront of unraveling the cell signaling mechanisms underlying key pathophysiological processes of PD, including mitochondrial dysfunction, oxidative stress, protein aggregation, exosome trafficking, neuroinflammation, and apoptosis. His lab recently discovered a novel mechanism involving epigenetic modifications in pesticide-induced neurotoxicity models.  In terms of translational research, they have been testing the efficacy of several small bioactive molecules, including mitochondria-targeted antioxidants and cell signaling modulators, against select therapeutic targets in various experimental models of PD, such as MPTP, 6-OHDA, and transgenic MitoPark mouse models, to advance them for further preclinical and clinical evaluations.

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Environmental Health Sciences Research Center | S300 CPHB | Iowa City, IA 52242-5000 | (319) 335-4756


The EHSRC is funded by NIH P30 ES005605

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