The Analytical Toxicology Laboratory, part of the EHSRC’s Exposure Science Facility (ESF), has moved to a newly renovated laboratory space in the Iowa Bioscience Innovation Facility (IBIF). This purpose-built laboratory space supports cutting-edge research on environmental exposures, the human microbiome, and molecular mechanisms of disease. It includes dedicated laboratories for molecular biology, microbiome research, sample preparation, chemical synthesis, and cell culture to support biomonitoring studies. The move was made possible by $7.5 million in institutional commitment and philanthropic funds. Several state-of-the-art instruments are available to analyze various chemical compounds in complex matrices, including water, food, air, blood and tissue samples:
- SCIEX Triple Quad 7500 System – QTRAP Ready (AB SCIEX, California) with an LC system (Agilent, Santa Clara, California) consisting of a High-Speed Pump solvent delivery system, Multicolumn Thermostat column oven, and Multisampler with Thermostat autosampler.
- Agilent Technologies 8890 gas chromatograph with 7693A Autoinjector and a 7000E Quadrupole MS/MS. This GC-MS/MS instrument is installed with Masshunter software on a dedicated, networked personal computer.
- Agilent Technologies 7890 gas chromatograph with 5975 single quadrupole mass spectrometer, inert EI ion source, and a CombiPAL sampler with SPME capability and an SPME fiber conditioning station. This instrument is operated with Masshunter software installed on a dedicated, networked personal computer.
- Agilent Technologies 6890N gas chromatograph with 5975 inert mass selective detector with EI or NCI ion sources, a micro electron capture detector, and a Gerstel MPS MulitPurpose Sampler with SPME capability. The instrument is operated with Masshunter software installed on a dedicated, networked personal computer.
- Shimadzu high pressure-liquid chromatography system consisting of a DGU-14A degaser, LC-10ATvp liquid chromatograph, SIL-10ADvp auto injector, SCL-10Avp system controller, CTO-20AC column oven, SPD-10Avp UV-VIS detector and FRC-10A fraction collector. This instrument operates with LabSolutions software and is installed on a dedicated personal computer.
Click here for more information about the EHSRC’s Core Facilities, including the Exposure Science Facility (ESF) and its Analytical Toxicology Laboratory (ATL).
