Center Affiliation and Expertise: Center Member, Nanotoxicology
The Haes Research Group focuses on synthesizing standard gold and/or silver nanostructures and subsequently modifying their surfaces with novel, perm-selective surface chemistries for the direct and quantitative detection of small molecules and metabolites. Surface enhanced Raman scattering (SERS) is used to directly detect the small molecules while the novel surface layers facilitate molecular transport and recognition specificity. In comparison to traditional biological recognition elements, perm-selective and/or imprinted surface chemistries replace antibodies and/or nucleic acid functionality and should be relatively more stable in terms of temperature, matrix, shelf life, and pH. Finally, these materials and detection platforms are integrated with macroscale (cuvette and well-plate) to capillary electrophoresis platforms for the ultimate analysis of small sample volumes with fast analysis times. Current applications include monitoring anti-cancer drug and hormone metabolism using label-free methods, detecting biomarkers in complex samples, and quantifying and identifying uranium in biological and environmental matrices.
- G. Lu, T.Z. Forbes, and A.J. Haes. SERS Detection of Uranyl using Functionalized Gold Nanostars promoted by Nanoparticle Shape and Size. Analyst, 2016, DOI: 10.1039/C6AN00891G.
- G. Lu, B.K. Shrestha, A.J. Haes. Importance of Tilt Angles of Adsorbed Aromatic Molecules on Nanoparticle Rattle SERS Substrates. Journal of Physical Chemistry C, 2016, DOI: 10.1021/acs.jpcc.6b02023.
- G. Lu, T.Z. Forbes, and A.J. Haes. Evaluating Best Practices in Raman Spectral Analysis for Uranium Speciation and Relative Abundance in Aqueous Solution. Analytical Chemistry, 2016, 88, 773-780.
- V.H. Grassian, A.J. Haes, I.A. Mudunkotuwa, P. Demokritou, A.B. Kane, C.J. Murphy, J.E. Hutchison, J.A. Issacs, Y-S Jun, B. Karn, S.I. Khondaker, S.C. Larsen, B.L.T. Lau, J.M. Pettibone, O.A. Sadik, N.B. Saleh, and C. Teague. NanoEHS – Defining Fundamental Science Needs: No Easy Feat when the Simple itself is Complex. Environmental Science: Nano, 2016, 3, 15-27.
- B.K. Shrestha and A.J. Haes. Improving Surface Enhanced Raman Signal Reproducibility using Gold-coated Silver Nanospheres Encapsulated in Silica Membranes. Journal of Optics, 2015, 17, 114017 (DOI://10.1088/2040-8978/17/11/114017).
- G. Lu, A.M. Goodman, B.A. Ayres, Z. Builta, and A.J. Haes. Near Real-Time Determination of Metabolic Parameters for Unquenched 6-Mercaptopurine and Xanthine Oxidase Samples using Capillary Electrophoresis. Journal of Pharmaceutical and Biomedical Analysis, 2015, 111, 51-56.
- L.A. Wijenayaka, M.R. Ivanov, C.M. Cheatum, and A.J. Haes. Improved Parametrization for Extended Derjaguin, Landau, Verwey, and Overbeek Predictions of Functionalized Gold Nanoparticle Stability. Journal of Physical Chemistry C, 2015, 119(18) 10064-10075.
- A.A. Volkert, M.S. Pierre, B. Shrestha, and A.J. Haes. Implications of Sample Aging on the Formation of Internally Etched Silica Coated Gold Nanoparticles. RCS Advances, 2015, 5, 3774-3780.
- A.A. Volkert and A.J. Haes. Advancements in Nanosensors using Plastic Antibodies. Analyst, 2014, 139(1) 21-31.
- M.S. Pierre and A.J. Haes. Purification Implications on SERS Activity of Silica Coated Gold Nanospheres. Analytical Chemistry, 2012, 84(18) 7906-7911.