Environmental Health Sciences Research Center

University of Iowa College of Public Health

  • Facebook
  • Twitter
  • Home
  • About
    • Overview
    • People
    • Membership Information
    • News
    • EHS Core Centers Meeting 2019
  • Resources & Opportunities
    • Pilot Grant Program
    • Career Enhancement Program
    • Seminars
    • NIEHS Funding Opportunities
    • BioBank Information
    • Disaster Response Protocol
  • Center Research
    • Publications
    • Research Themes
    • Core Facilities
  • Community Engagement
    • About the Community Engagement Core
    • Activities & Services
    • Resources & Information
    • Science Café
  • Contact
  • Response to COVID-19
You are here: Home / Team Showcase / Joseph Zabner, MD

Joseph Zabner, MD

December 4, 2018 By

Center Affiliation and Expertise: Inflammation and Innate Immunity

Dr. Zabner has significant experience at basic CF research, clinical CF research, and the care of patients with lung disease, including CF. Several aspects of his research would be best classified as translational research. His basic research focuses in two areas, gene transfer to airway epithelia, including the basic mechanisms and development of new approaches to gene transfer, and investigation of the pathogenesis of CF airway disease, including mechanisms of electrolyte transport and bacterial killing. The main goal of his current gene therapy efforts include work is to improve efficiency of adenovirus-mediated gene transfer to the airways. Dr. Zabner’s laboratory is also involved in delineating mechanisms of altered NaCl concentration in the airway surface fluid (ASF) of CF as compared to non-CF epithelia. To address these questions, he uses primary cultures of normal and CF airway epithelia to measure ion concentrations of ASF. Three different methods including ion-selective electrodes, measurement of ASF in which the capillary pressure of the cilia is replaced by osmotic pressure from a non-absorbed osmolyte, and radioactive tracers studied at equilibrium, are used to address these issues. The results of these studied are central to understanding how the lack of CFTR Cl- channels causes CF lung disease.

http://www.healthcare.uiowa.edu/labs/zabner/

Complete List of Published Work

Sign up for Email Updates

Stay up-to-date with the latest from the EHSRC.
  • This field is for validation purposes and should be left unchanged.

EHSRC Logo

Environmental Health Sciences Research Center | S300 CPHB | Iowa City, IA 52242-5000 | (319) 335-4756


The EHSRC is funded by NIH P30 ES005605

National Institute of Environmental Health Sciences logo


© The College of Public Health - The University of Iowa. All rights reserved. | Accessibility Statement