Center Affiliation and Expertise: Co-Director, Pulmonary Toxicology Facility (PTF)
Dr. Adamcakova-Dodd is Co-Director of the Pulmonary Toxicology Facility (PTF) of the EHSRC. She joined the PTF as a toxicologist in 2002 and has extensive experience conducting toxicological studies using in vitro and in vivo models. She has led or collaborated on toxicity studies of various inhaled particulate aerosols (metal and metal oxide nanoparticles, and carbon nanotubes), vapors (polychlorinated biphenyls mixture or individual congeners), metal working fluids, endotoxin, inhaled biological agents (including pathogenic microorganisms), xylitol, gallium nitrate, organic dust, and toxic gases (chlorine and phosphine). She is experienced with a variety of generation systems for dry and wet aerosols, vapors, and gases, as well as in vitro models at air-liquid interface and multiple in vivo inhalation models (acute, sub-acute of sub-chronic) in mice and rats and with the assessment of a wide array of biomarkers. She also has experience with several lung injury models including inflammation (induced by endotoxin or particulate matter), asthma (house dust mite allergen), hypersensitivity pneumonitis (metalworking fluid), pulmonary fibrosis (bleomycin or crystalline silica), and acute lung injury (caused by high concentration of sulfur dioxide, chlorine and phosphine gas). She has expertise necessary to perform inhalation exposures (nose-only or whole-body), nasal and intra-tracheal instillations, pharyngeal aspirations, i.m. and i.p. injections, anesthesia, pulmonary functions and mechanics measurements, euthanasia, bronchoalveolar lavage, blood collection, and tissue harvesting in small rodents. She regularly trains graduate students, postdoctoral fellows and research staff.
List of publications:
https://www.ncbi.nlm.nih.gov/myncbi/1z7R7pKYpxyAU/bibliography/public/