Dr. Lynch’s major research interest center around population-based research involving a cancer surveillance program (Iowa Cancer Registry) and cancer epidemiology and surveillance, cancer pathology, and environmental epidemiology.
Selected Publications:
1. Reiner AS, Malone KE, Lynch CF, Mellemkjær L, Knight JA, John EM, Liang X, Woods M; WECARE Study Collaborative Group; Bernstein JL. Risk factors for estrogen receptor subtype-specific contralateral breast cancer in women under age 55 years. International Journal of Cancer 2026 Aug 7. Online ahead of print. PMID42563563
2. Lee S, Shu X, Derkach A, Reiner AS, Liang X, Woods M, Concannon P, Lynch CF, Malone KE, Knight JA, John EM, Deasy JO, Bernstein JL, Oh JH. Integrating genomic and non-genomic data to stratify the risk of contralateral breast cancer after radiotherapy. International Journal of Radiation Oncology, Biology and Physics 2026 Aug 1;125(5):1512-1521. PMID41763494, PMC13051349
3. Tao J, Pfeiffer R, Ahmed S, Luo Q, Qian B, Lynch CF, Insaf T, Ramirez-Aguilar D, Israni A, Morton LM, Engels EA. Cancer risk in solid organ transplant recipients with a pretransplant cancer history. JAMA Oncology 2026 May 1;12(5):470-477. PMID41817522, PMC13195476
4. Naderi E, Watt GP, Knight JA, Malone KE, Lynch CF, John EM, Shu X, Nguyen TL, Oh JH, Woods M, Liang X, Derkach A, Pike MC, Bernstein JL Evaluating mammographic density polygenic risk score for contralateral breast cancer risk prediction. Scientific Reports 2026 Mar 4;16(1):12125. PMID41781474
5. Watt GP, Reiner AS, Shu X, Malone KE, Knight JA, John EM, Chow EJ, Lynch CF, Mellemkjær L, Woods M, Liang X, Tran AP, Oh JH, Derkach A, Bernstein JL. Polygenic risk of coronary artery disease for long-term survivors of breast cancer. Journal of the National Cancer Institute 2025 Oct 1;117(10):2073-2081. PMID40665521, PMC12505140
6. Ahmed S, Pfeiffer RM, Volesky-Avellaneda K, Blosser CD, Snyder JJ, Israni AK, Lynch CF, Qiao B, Rees JR, Zwald F, Yu KJ, Engels EA. Real-world evidence regarding cancer, mortality, and graft failure risk with de novo belatacept use among kidney transplant recipients in the United States. American Journal of Transplantation 2025 Aug;25(8):1723-1734. PMID40064297, PMC12310376 (Editor’s Choice article for the March issue)
7. Jackson SS, Pfeiffer RM, Gardner E, Hsieh MC, Insaf T, Lynch CF, B Morawski, Wang S, Yu KJ, Engels EA. Sex differences in cancer survival among solid organ transplant recipients. International Journal of Cancer 2025 Aug 1;157(3):427-435. PMID40347031, PMC12143962
8. Engels EA, Mandal S, Corley DA, Blosser CD, Hart A, Lynch CF, Qiao B, Pawlish KS, Haber G, Yu KJ, Pfeiffer RM. Cure models, survival probabilities, and solid organ transplantation for patients with colorectal cancer. American Journal of Transplantation 2025 Mar;25(3):545-555. PMID39182612, PMC11842210
9. Debeljak M, Cho S, Downs BM, Considine M, Avin-McKelvey B, Wang Y, Perez PN, Grizzle WE, Hoadley KA, Lynch CF, Hernandez BY, van Diest PJ, Cozen W, Hamilton AS, Hawes D, Gabrielson E, Cimino-Mathews A, Florea LD, Cope L, Umbricht CB. Multimodal genome-wide survey of progressing and non-progressing breast ductal carcinoma in-situ. Breast Cancer Research 2024 Dec 4;26(1):178. PMID39633428
10. Reiner AS, Watt GP, Malone KE, Lynch CF, John EM, Knight JA, Woods M, Liang X, Tishkowitz M, Conti DV, Robson ME, Mellemkjær L, Teraoka SN, Concannon P, Bernstein JL. Breast cancer susceptibility gene sequence variations and development of contralateral breast cancer. JAMA Network Open 2024 Dec 2;7(12):e2452158. PMID39786405
11. Starrett GJ, Baikie BC, Stoff BK, Grossniklaus HE, Van Buren I, Berry EG, Novoa RA, Rieger KE, Sarin KY, Lynch CF, Royer MC, Piaskowski ML, Brownell I, Chu EY, Godse R, Chen SC, Yu KJ, Goldstein AM, Engels EA, Sargen MR. Multiomics profiling distinguishes sebaceous carcinoma from benign sebaceous neoplasms and provides insight into the genetic evolution of sebaceous carcinogenesis. Clinical Cancer Research 2024 Nov 1;30(21):4887-4899. PMID39287419, PMC11530307
12. Dennis LK, Langston ME, Beane Freeman L, Canales RA, Lynch CF. Trace element concentrations of arsenic and selenium in toenails and risk of prostate cancer among pesticide applicators. Current Oncology 2024 Sep 14;31(9):5472-5483. PMID39330033
13. Sanchez P, Van Dyke AL, Petkov VI, Yuan Y, Bonds S, Valenzuela C, Tuan AW, Moravec R, Altekruse SF, Singhi AD, Serdy KM, Wu Y, Cress RD, Doherty JA, Mueller L, Hernandex BY, Lynch CF, Tucker TC, Wu XC, Matrisian L, Penberthy L. NCI SEER-linked virtual tissue repository pilot. J Natl Cancer Inst Monographs 2024 Aug 1;2024(65):180-190. PMID39102878
14. Sun X, Verma SP, Jia G, Wang X, Ping J, Guo X, Shu XO, Chen J, Derkach A, Cai Q, Liang X, Long J, Offit K, Oh JH, Reiner AS, Watt GP, Woods M, Yang Y, Ambrosone CB, Ambs S, Chen Y, Concannon P, Garcia-Closas M, Gu J, Haiman CA, Hu JJ, Huo D, John EM, Knight JA, Li CI, Lynch CF, Mellemkjaer L, Nathanson KL, Nemesure B, Olopade OI, Olshan AF, Pal T, Palmer JR, Press MF, Sanderson M, Sandler DP, Troester MA, Zheng W, Bernstein JL, Buas MF, Shu X. Case-case genome-wide analyses identify subtype-informative variants that confer risk for breast cancer. Cancer Research 2024 Aug 1;84(15):2533-2548. PMID38832928, PMC11293972
15. Zwald FO, Sargen MR, Austin AA, Hsieh MC, Pawlish K, Li J, Lynch CF, Yu KJ, Engels EA. Outcomes in solid organ transplant recipients with a pretransplant diagnosis of melanoma. American Journal of Transplantation 2024 Jun;24(6):993-1002. PMID38387619, PMC11144558
16. Sun X, Reiner AS, Tran AP, Watt GP, Oh JH, Mellemkjær L, Lynch CF, Knight JA, John EM, Malone KE, Liang X, Woods M, Derkach A, Concannon P, Bernstein JL, Shu X. A genome-wide association study of contralateral breast cancer in the Women’s Environmental Cancer and Radiation Epidemiology Study. Breast Cancer Research 2024 Jan 23;26(1):16. PMID38263039
17. Mix JM, Miller MJ,Querec TD, Darragh TM, Saraiya M, Gopalani SV, Lynch CF, Thompson TD, Greek A, Tucker TC, Peters ES, Unger ER. Human Papillomavirus Detection in Scrotal Squamous Cell Carcinoma: Case Series from a Population-Based Cancer Registry. Journal of Registry Management 2023 Winter;50(4):116-121. PMID38504701
18. Wang JH, Pfeiffer RM, Musgrove D, Castenson D, Frederickson M, Miller J, Gonsalves L, Hsieh MC, Lynch CF, Zeng Y, Yu KJ, Hart A, Israni AK, Snyder JJ, Engels EA. Cancer mortality among solid organ transplant recipients in the United States during 1987-2018. Transplantation 2023 Nov 1;107(11):2433-2442. PMID37291711, PMC10615843
19. Watt GP, Smith SA, Howell RM, Pérez-Andújar A, Reiner AS, Cerviño L, McCormick B, Hess D, Knight JA, Malone KE, John EM, Bernstein L, Lynch CF, Mellemkjær L, Shore RE, Liang X, Woods M, Boice JD, Dauer LT, Bernstein JL. Trends in radiation dose to the contralateral breast during breast radiation therapy. Radiation Research 2023 Oct 1;200(4):331-339. PMID37590492, PMC10684055
20. Chaturvedi AK, Engels EA, Pfeiffer RM, Hernandez BY, Xiao W, Kim E, Jiang B, Goodman MT, Siburg-Saber M, Cozen W, Liu L, Lynch CF, Wentzensen N, Jordan RC, Altekruse S, Anderson WF, Rosenberg PS, Gillison ML. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. Journal of Clinical Oncology 2023 41(17):3081-3088. PMID37285653, PMC10538911 Corrected and republished from Journal of Clinical Oncology 29(32):4294-4301, 2011.
21. Sadeghi H, Charles Lynch, Field W, Snetselaar L, Jones M, Sinha R, Torner J. Dietary omega-6/omega-3 fatty acids and risk of prostate cancer; Is there .any potential interaction by organophosphate insecticides among the Agricultural Health Study population. Cancer Epidemiology 2023 Aug;85:102410. PMID37413804, PMC10528409
22. Tanaka T, Lynch CF, Yu K, Morawski BM, Hsieh MC, Alverson G, Austin AA, Zeng Y, Engels EA. Pancreatic cancer among solid organ transplant recipients in the United States. Journal of Cancer Research and Clinical Oncology 2023 Jul;149(7):3325-3333. PMID35932302
23. Starrett GJ, Yu K, Golubeva Y, Lenz P, Piaskowski ML, Petersen D, Dean M, Israni A, Hernandez BY, Tucker TC, Cheng I, Gonsalves L, Morris CR, Hussain SK, Lynch CF, Harris RS, Prokunina-Olsson L, Meltzer PS, Buck CB, Engels EA. Evidence for virus-mediated oncogenesis in bladder cancers arising in solid organ transplant recipients. eLife 2023 Mar 24;12:e82690. PMID36961501
24. Hart A, Pfeiffer RM, Morawski BM, Lynch CF, Zeng Y, Pawlish K, Hurley D, Yu KJ, Engels EA. Mortality in solid organ transplant recipients with a pretransplant cancer diagnosis. American Journal of Transplantation 2023 Feb;23(2):257-264. PMID36804133, PMC9978936
25. Watt GP, Knight JA, Nguyen TL, Reiner AS, Malone KE, John EM, Lynch CF, Brooks JD, Woods M, Liang X, Bernstein L, Pike MC, Hopper JL, Bernstein JL. Association of contralateral breast cancer risk with mammographic density defined at higher-than-conventional intensity thresholds. International Journal of Cancer 2022 Oct 15;151(8):1304-1309. PMID35315524
26. Riley D, Charlton M, Chrischilles EA; Lizarraga IM, Phadke S; Smith BJ, Skibbe A, Lynch CF. Hospital rurality and gene expression profiling for early-stage breast cancer among Iowa residents, 2010-2018. The Breast Journal Aug 30;2022:8582894. PMID36111211
27. Engels EA, Fraser GE, Kasiske BL, Snyder JJ, Utt J, Lynch CF, Li J, Pawlish KS, Brown S, Yu KJ, Pfeiffer RM. Cancer risk in living kidney donors. American Journal of Transplantation 2022 Aug;22(8):2006-2015. PMID35510728, (featured on the cover of the August issue)
28. Riley D, Chrischilles EA, Lizarraga IM, Charlton M, Smith BJ, Lynch C. Rural-urban differences in secular trends of locoregional treatment for ductal carcinoma in situ: A patterns of care analysis. Cancer Medicine 2022 Jun;11(11):2284–2295. PMID35146946
29. Reiner AS, Watt GP, John EM, Lynch CF, Brooks JD, Mellemkjær L, Boice JD, Knight JA, Concannon P, Smith SA, Liang X, Woods M, Shore R, Malone KE, Bernstein L; WECARE Collaborative Study Group, Bernstein JL. Smoking, radiation therapy, and contralateral breast cancer risk in young women. Journal of the National Cancer Institute 2022 Apr 11;114(4):631-634. PMID33779721
30. Sargen MR, Cahoon EK, Yu KJ, Madeleine MM , Zeng Y, Rees JR, Lynch CF, Engels EA. Spectrum of nonkeratinocyte skin cancer risk among solid organ transplant recipients in the US. JAMA Dermatology 2022 Apr 1;158(4):414-425. PMID35262623, PMC8908231
31. Riley D, Chrischilles EA, Lizarraga IM, Charlton M, Smith BJ, Lynch CF. Influence of rurality on lymph node assessment among women diagnosed with ductal carcinoma in situ and treated with mastectomy, SEER 2000-2015. Breast Cancer Research and Treatment 2022 Feb;192(1):211-222. PMID35067778
32. Langston ME, Brown HE, Lynch CF, Roe DJ, Dennis LK. Ambient UVR and environmental arsenic exposure in relation to cutaneous melanoma in Iowa. International Journal of Environmental Research and Public Health 2022 Feb 3;19(3):1742. PMID35162766
33. Weeks KS, Lynch CF, West M, Carnahan R, O’Rorke M, Oleson J, McDonald M, Stewart SL, Ovarian Cancer Treatment Study, Charlton M. Gynecologic oncologist impact on adjuvant chemotherapy care for stage II-IV ovarian cancer patients. Gynecologic Oncology 2022 Jan;164(1):3-11 (Editor’s Choice article for the January 2022 issue). PMID34776243
34. Noone AM, Pfeiffer RM, Schaubel DE, Dorgan JF, Magder LS, Bromberg JS, Lynch CF, Morris CR, Pawlish KS, Engels EA. Life-years lost to cancer among solid organ transplant recipients in the United Sates, 1987 to 2014. Cancer 2022 Jan 1;128(1):150-159. PMID34541673