Environmental Health Sciences Research Center

University of Iowa College of Public Health

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David L. Roman, PhD

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Thoughout his career, Dr. Roman has focused on investigating novel targets for therapeutic intervention, using high throughput screening as a tool. He has longstanding interests in 1) targeting regulators of GPCR signals as novel drug targets, 2) exploiting novel targets for therapeutic intervention in cancer, 3) the development of novel methodologies to measure protein-protein interactions and function, 4) the design and implementation of high throughput technologies for lead development, and 5) the impact of environmental contaminants such as PFAS on GPCR signaling pathways.

Selected Publications:

  1. Wilkinson J. C., Lehmler H.-J., & Roman D. L. (2024) High-Throughput GPCRome Screen of Pollutants Reveals the Activity of Polychlorinated Biphenyls at Melatonin and Sphingosine-1-phosphate Receptors. Chemical research in toxicology 37(2):439–49. doi: 10.1021/acs.chemrestox.3c00388. PMID: 38295294. PMCID: PMC10880096
  2. Roman D. L. A new angle on RGS protein modulation. Trends Pharmacol Sci. 2025;46(9):829–31. doi: 10.1016/j.tips.2025.07.012. PMID: 40752996
  3. Dwyer, T. S., O’Brien, J. B., Ptak, C. P., LaVigne, J. E., Flaherty, D. P., Watts, V. J. & Roman, D. L. (2022). Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype. Frontiers in pharmacology 13 977742. DOI: 10.3389/fphar.2022.977742. PMID: 36147328. PMCID: PMC9486168.
  4. Cagle, B. S., Sturgeon, M. L., O’Brien, J. B., Wilkinson, J. C., Cornell, R. A., Roman, D. L. & Doorn, J. A. (2021). Stable expression of the human dopamine transporter in N27 cells as an in vitro model for dopamine cell trafficking and metabolism. Toxicology in vitro : an international journal published in association with BIBRA 76 105210. DOI: 10.1016/j.tiv.2021.105210. PMID: 34252731. PMCID: PMC8419135.
  5. O’Brien, J. B. & Roman, D. L. (2021). Novel treatments for chronic pain: moving beyond opioids. Translational research : the journal of laboratory and clinical medicine 234 1-19. DOI: 10.1016/j.trsl.2021.03.008. PMID: 33727192.
  6. Hayes, M. P., O’Brien, J. B., Crawford, R. A., Fowler, C. A., Yu, L., Doorn, J. A. & Roman, D. L. (2021). Fragment-Based Nuclear Magnetic Resonance Screen against a Regulator of G Protein Signaling Identifies a Binding “Hot Spot”. Chembiochem : a European journal of chemical biology 22 (9) 1609-1620. DOI: 10.1002/cbic.202000740. PMID: 33480159. PMCID: PMC8546901.
  7. O’Brien, J. B., Wilkinson, J. C. & Roman, D. L. (2019). Regulator of G-protein signaling (RGS) proteins as drug targets: Progress and future potentials. The Journal of biological chemistry 294 (49) 18571-18585. DOI: 10.1074/jbc.REV119.007060. PMID: 31636120. PMCID: PMC6901330.
  8. Sieng, M., Hayes, M. P., O’Brien, J. B., Andrew Fowler, C., Houtman, J. C., Roman, D. L. & Lyon, A. M. (2019). High-resolution structure of RGS17 suggests a role for Ca(2+) in promoting the GTPase-activating protein activity by RZ subfamily members. The Journal of biological chemistry 294 (20) 8148-8160. DOI: 10.1074/jbc.RA118.006059. PMID: 30940727. PMCID: PMC6527179.
  9. Bodle, C. R., Schamp, J. H., O’Brien, J. B., Hayes, M. P., Wu, M., Doorn, J. A. & Roman, D. L. (2018). Screen Targeting Lung and Prostate Cancer Oncogene Identifies Novel Inhibitors of RGS17 and Problematic Chemical Substructures. SLAS discovery : advancing life sciences R & D 23 (4) 363-374. DOI: 10.1177/2472555217752301. PMID: 29351497. PMCID: PMC6342279.
  10. Hayes, M. P., Soto-Velasquez, M., Fowler, C. A., Watts, V. J. & Roman, D. L. (2018). Identification of FDA-Approved Small Molecules Capable of Disrupting the Calmodulin-Adenylyl Cyclase 8 Interaction through Direct Binding to Calmodulin. ACS chemical neuroscience 9 (2) 346-357. DOI: 10.1021/acschemneuro.7b00349. PMID: 28968502. PMCID: PMC6362833.
  11. Hayes, M. P., Bodle, C. R. & Roman, D. L. (2018). Evaluation of the Selectivity and Cysteine Dependence of Inhibitors across the Regulator of G Protein-Signaling Family. Molecular pharmacology 93 (1) 25-35. DOI: 10.1124/mol.117.109843. PMID: 29051318. PMCID: PMC5708088.