Dr. Eric A. Hoffman, Ph.D. received his Ph.D. in Physiology from the University of Minnesota / Mayo Graduate School of Medicine in 1981 and remained on staff at the Mayo Clinic where he was a member of the team which Developed the Dynamic Spatial Reconstructor (DSR), the earliest volumetric X-Ray computed tomographic scanner. He currently is the director of the Advanced Pulmonary Physiomics Laboratory (APPIL) at the University of Iowa. Throughout his career, Dr. Hoffman has used advanced imaging methodologies to study basic respiratory physiology centered largely on mechanisms of ventilation and perfusion heterogeneity and regional lung mechanics. In the late 1970s, volumetric computed tomography was used to provide a first look at regional lung mechanics in the never invaded negative pressure environment of the intact thorax. Hoffman’s contributions have served to illuminate many underlying relationships in COPD, Asthma and environmental lung diseases. Recent work has led to the investigation of vascular dysfunction in the etiology of emphysema based upon novel uses of dual energy multidetector row CT (DECT). A key contribution of Dr. Hoffman’s work lies in the continued efforts to provide analysis tools, coordination, quality control and image analysis to support NIH sponsored multi-center studies (NETT, MESA Lung, SPIROMICS, SARP, PrecISE, etc.) whereby imaging of the lung serves to explore novel phenotypes or to provide outcomes measures related to interventions. The APPIL laboratory includes a research dedicated, state-of-the-art photon-counting CT scanner (Siemens Naeotom Alpha) supported, in part, through an NIH high-end shared instrumentation grant.