Environmental Health Sciences Research Center

University of Iowa College of Public Health

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Kai Wang, PhD

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Center Affiliation and Expertise: Integrative Health Sciences Facility

Dr. Kai Wang is a faculty member in Department of Biostatistics. His research interests include application and development of statistical technologies related to biomedical studies including analysis of PCBs, bioinformatics, and statistical genetics.

Publications:

  • Jacobus JA, Wang B, Maddox C, Esch H, Lehmann L, Robertson LW, Wang K, Kirby P, Ludewig G. 3-Methylcholanthrene (3-MC) and 4-Chlorobiphenyl (PCB3) genotoxicity is gender-related in Fischer 344 transgenic rats. Environment International, 36(8):970-979, 2010. PMID: 20739065, PMCID: PMC2949545
  • Wang B, Robertson L, Wang K, Ludewig G. Species difference in the regulation of cytochrome P450 2S1: lack of induction in rats by the aryl hydrocarbon receptor agonist PCB126. Xenobiotica. 41(12):1031-1043, 2011. PMID: 21970748, PMCID: PMC3564674
  • Lai IK, Klaren W, Li M, Wels B, Simmons D, Olivier A, Haschek-Hock W, Wang K., Ludewig G, Robertson LW. Does Dietary Copper Supplementation enhance or diminish PCB126 Toxicity in Rodent Liver?. Chemical Research in Toxicology. 26(5):634-644, 2013. PMID: 23527585, PMCID: PMC3660509
  • Marek R, Thorne P, Wang K, DeWall J, Hornbuckle K. PCBs and OH-PCBs in Serum from Children and Mothers in Urban and Rural U.S. Communities. Environmental Science & Technology. 47(7):3353-3361, 2013. PMID: 23452180, PMCID: PMC3645264
  • Wang K, Huang J, Vieland VJ. The consistency of the posterior probability of linkage. Ann Hum Genet. 2000 Nov;64(Pt 6):533-53. PubMed PMID: 11281217.
  • Wang K, Huang J. A score-statistic approach for the mapping of quantitative-trait loci with sibships of arbitrary size. Am J Hum Genet. 2002 Feb;70(2):412-24. PubMed PMID: 11791211; PubMed Central PMCID: PMC384916.
  • Wang K. A likelihood approach for quantitative-trait-locus mapping with selected pedigrees. Biometrics. 2005 Jun;61(2):465-73. PubMed PMID: 16011693.
  • Wang K, Abbott D. A principal components regression approach to multilocus genetic association studies. Genet Epidemiol. 2008 Feb;32(2):108-18. PubMed PMID: 17849491.
  • Martinez A, Wang K, Hornbuckle KC. Fate of PCB congeners in an industrial harbor of Lake Michigan. Environ Sci Technol. 2010 Apr 15;44(8):2803-8. PubMed PMID: 20131898; PubMed Central PMCID: PMC3257175.
  • Lai IK, Chai Y, Simmons D, Watson WH, Tan R, Haschek WM, Wang K, Wang B, Ludewig G, Robertson LW. Dietary selenium as a modulator of PCB 126-induced hepatotoxicity in male Sprague-Dawley rats. Toxicol Sci. 2011 Nov;124(1):202-14. PubMed PMID: 21865291; PubMed Central PMCID: PMC3196656.
  • Marek RF, Thorne PS, Wang K, Dewall J, Hornbuckle KC. PCBs and OH-PCBs in serum from children and mothers in urban and rural U.S. communities. Environ Sci Technol. 2013 Apr 2;47(7):3353-61. PubMed PMID: 23452180; PubMed Central PMCID: PMC3645264.
  • Lai IK, Klaren WD, Li M, Wels B, Simmons DL, Olivier AK, Haschek WM, Wang K, Ludewig G, Robertson LW. Does dietary copper supplementation enhance or diminish PCB126 toxicity in the rodent liver?. Chem Res Toxicol. 2013 May 20;26(5):634-44. PubMed PMID: 23527585; PubMed Central PMCID: PMC3660509.
  • Sohn EH, Flamme-Wiese MJ, Whitmore SS, Wang K, Tucker BA, Mullins RF. Loss of CD34 expression in aging human choriocapillaris endothelial cells. PLoS One. 2014;9(1):e86538. PubMed PMID: 24466138; PubMed Central PMCID: PMC3897719.
  • Mullins RF, Schoo DP, Sohn EH, Flamme-Wiese MJ, Workamelahu G, Johnston RM, Wang K, Tucker BA, Stone EM. The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning. Am J Pathol. 2014 Nov;184(11):3142-53. PubMed PMID: 25204844; PubMed Central PMCID: PMC4215023.
  • Stunkel M, Bhattarai S, Kemerley A, Stone EM, Wang K, Mullins RF, Drack AV. Vitritis in pediatric genetic retinal disorders. Ophthalmology. 2015 Jan;122(1):192-9. PubMed PMID: 25217415; PubMed Central PMCID: PMC4277925.
  • Sohn EH, Wang K, Thompson S, Riker MJ, Hoffmann JM, Stone EM, Mullins RF. Comparison of drusen and modifying genes in autosomal dominant radial drusen and age-related macular degeneration. Retina. 2015 Jan;35(1):48-57. PubMed PMID: 25077532.
  • Fabbro S, Kahr WH, Hinckley J, Wang K, Moseley J, Ryu GY, Nixon B, White JG, Bair T, Schutte B, Di Paola J. Homozygosity mapping with SNP arrays confirms 3p21 as a recessive locus for gray platelet syndrome and narrows the interval significantly. Blood. 2011 Mar 24;117(12):3430-4. PubMed PMID: 21263149; PubMed Central PMCID: PMC3069679.
  • Kahr WH, Hinckley J, Li L, Schwertz H, Christensen H, Rowley JW, Pluthero FG, Urban D, Fabbro S, Nixon B, Gadzinski R, Storck M, Wang K, Ryu GY, Jobe SM, Schutte BC, Moseley J, Loughran NB, Parkinson J, Weyrich AS, Di Paola J. Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome. Nat Genet. 2011 Jul 17;43(8):738-40. PubMed PMID: 21765413.
  • Hinckley JD, Abbott D, Burns TL, Heiman M, Shapiro AD, Wang K, Di Paola J. Quantitative trait locus linkage analysis in a large Amish pedigree identifies novel candidate loci for erythrocyte traits. Mol Genet Genomic Med. 2013 Sep 1;1(3):131-141. PubMed PMID: 24058921; PubMed Central PMCID: PMC3775389.
  • Gonzalez-Alegre P, Di Paola J, Wang K, Fabbro S, Yu HC, Shaikh TH, Darbro BW, Bassuk AG. Evaluating Familial Essential Tremor with Novel Genetic Approaches: Is it a Genotyping or Phenotyping Issue?. Tremor Other Hyperkinet Mov (N Y). 2014;4:258. PubMed PMID: 25374765; PubMed Central PMCID: PMC4219111.
  • Gonzalez-Alegre P, Buffard V, Wang K, Henien S, Morcuende JA. Exploring the link between dystonia genes and idiopathic scoliosis. J Pediatr Orthop. 2013 Sep;33(6):e65-6. PubMed PMID: 23812140.
  • Seo S, Mullins RF, Dumitrescu AV, Bhattarai S, Gratie D, Wang K, Stone EM, Sheffield V, Drack AV. Subretinal gene therapy of mice with Bardet-Biedl syndrome type 1. Invest Ophthalmol Vis Sci. 2013 Sep 11;54(9):6118-32. PubMed PMID: 23900607; PubMed Central PMCID: PMC3771708.
  • Fisher JT, Tyler SR, Zhang Y, Lee BJ, Liu X, Sun X, Sui H, Liang B, Luo M, Xie W, Yi Y, Zhou W, Song Y, Keiser N, Wang K, de Jonge HR, Engelhardt JF. Bioelectric characterization of epithelia from neonatal CFTR knockout ferrets. Am J Respir Cell Mol Biol. 2013 Nov;49(5):837-44. PubMed PMID: 23782101; PubMed Central PMCID: PMC3931095.
  • Bu F, Maga T, Meyer NC, Wang K, Thomas CP, Nester CM, Smith RJ. Comprehensive genetic analysis of complement and coagulation genes in atypical hemolytic uremic syndrome. J Am Soc Nephrol. 2014 Jan;25(1):55-64. PubMed PMID: 24029428; PubMed Central PMCID: PMC3871781.