Environmental Health Sciences Research Center

University of Iowa College of Public Health

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Maureen Donovan, PhD

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Center Affiliation and Expertise: Nanotoxicology; Population Health

Dr. Donovan’s laboratory has been actively investigating the absorption of compounds via the nasal cavity for over 20 years. Current research is focused on identifying the mechanisms controlling the preferential disposition of materials absorbed across the nasal mucosa and transferred to the CNS. The lab is examining the ability of uptake and efflux transporters, along with endocytotic processes to transfer materials from the nasal cavity to the brain while bypassing the blood-brain barrier. With the increasing interest in the ability of inhaled environmental contaminants reaching the brain via the nasal/olfactory pathways,Dr. Donovan’s lab has initiated new investigations in the uptake of nanoparticles and other environmental toxins into the brain.

Publications:

  • Dhamankar V, Assem M, Donovan MD. Gene expression and immunochemical localization of major cytochrome P450 drug-metabolizing enzymes in bovine nasal olfactory and respiratory mucosa. Inhal Toxicol. 2015 Dec;27(14):767-77. PubMed PMID: 26572092.
  • Al-Ghabeish M, Scheetz T, Assem M, Donovan MD. Microarray Determination of the Expression of Drug Transporters in Humans and Animal Species Used for the Investigation of Nasal Absorption. Mol Pharm. 2015 Aug 3;12(8):2742-54. PubMed PMID: 26106909; PubMed Central PMCID: PMC4671632.
  • Chemuturi NV, Donovan MD. Role of organic cation transporters in dopamine uptake across olfactory and nasal respiratory tissues. Mol Pharm. 2007 Nov-Dec;4(6):936-42. PubMed PMID: 17892261.
  • Shah AJ, Donovan MD. Rheological characterization of neutral and anionic polysaccharides with reduced mucociliary transport rates. AAPS PharmSciTech. 2007 Apr 20;8(2):Article 32. PubMed PMID: 17622110; PubMed Central PMCID: PMC2750371.
  • Zhang H, Lin CW, Donovan MD. Correlation between nasal membrane permeability and nasal absorption rate. AAPS PharmSciTech. 2013 Mar;14(1):60-3. PubMed PMID: 23225081; PubMed Central PMCID: PMC3581654.
  • Chemuturi NV, Hayden P, Klausner M, Donovan MD. Comparison of human tracheal/bronchial epithelial cell culture and bovine nasal respiratory explants for nasal drug transport studies. J Pharm Sci. 2005 Sep;94(9):1976-85. PubMed PMID: 16052562.
  • Huang Y, Donovan MD. Large molecule and particulate uptake in the nasal cavity: the effect of size on nasal absorption. Adv Drug Deliv Rev. 1998 Jan 5;29(1-2):147-155. PubMed PMID: 10837585.
  • Huang Y, Donovan MD. Microsphere Transport Pathways in the Rabbit Nasal Mucosa. International Journal of Pharmaceutical Advances. 1996; 1:298-309.
  • Xu J, Li G, Wang Z, Si L, He S, Cai J, Huang J, Donovan MD. The role of L-type amino acid transporters in the uptake of glyphosate across mammalian epithelial tissues. Chemosphere. 2015 Dec 14;145:487-494. PubMed PMID: 26701683.
  • Al-Ghabeish M, Scheetz T, Assem M, Donovan MD. Microarray Determination of the Expression of Drug Transporters in Humans and Animal Species Used for the Investigation of Nasal Absorption. Mol Pharm. 2015 Aug 3;12(8):2742-54. PubMed PMID: 26106909; PubMed Central PMCID: PMC4671632.
  • Huang Y, Donovan MD. Large molecule and particulate uptake in the nasal cavity: the effect of size on nasal absorption. Adv Drug Deliv Rev. 1998 Jan 5;29(1-2):147-155. PubMed PMID: 10837585.
  • Donovan MD, Flynn GL, Amidon GL. Absorption of polyethylene glycols 600 through 2000: the molecular weight dependence of gastrointestinal and nasal absorption. Pharm Res. 1990 Aug;7(8):863-8. PubMed PMID: 2235883.
  • Dhamankar V, Assem M, Donovan MD. Gene expression and immunochemical localization of major cytochrome P450 drug-metabolizing enzymes in bovine nasal olfactory and respiratory mucosa. Inhal Toxicol. 2015 Dec;27(14):767-77. PubMed PMID: 26572092.
  • Zhang H, Prisinzano TE, Donovan MD. Permeation and metabolism of cocaine in the nasal mucosa. Eur J Drug Metab Pharmacokinet. 2012 Dec;37(4):255-62. PubMed PMID: 22351075.
  • Chemuturi NV, Donovan MD. Metabolism of dopamine by the nasal mucosa. J Pharm Sci. 2006 Nov;95(11):2507-15. PubMed PMID: 16917843.
  • Chung FY, Donovan MD. Nasal Pre-systemic Metabolism of Peptide Drugs: Substance P Metabolism in the Sheep Nasal Cavity. International Journal of Pharmaceutics. 1996; 128:229-237.
  • Khanvilkar K, Donovan MD, Flanagan DR. Drug transfer through mucus. Adv Drug Deliv Rev. 2001 Jun 11;48(2-3):173-93. PubMed PMID: 11369081.
  • Bhat PG, Flanagan DR, Donovan MD. Drug diffusion through cystic fibrotic mucus: steady-state permeation, rheologic properties, and glycoprotein morphology. J Pharm Sci. 1996 Jun;85(6):624-30. PubMed PMID: 8773960.
  • Pavan BG, Flanagan DR, Donovan MD. Drug Binding to Gastric Mucus Glycoproteins. International Journal of Pharmaceutics. 1996; 134:15-25.
  • Shah AJ, Donovan MD. Formulating gels for decreased mucociliary transport using rheologic properties: polyacrylic acids. AAPS PharmSciTech. 2007 Apr 20;8(2):Article 33. PubMed PMID: 17622111; PubMed Central PMCID: PMC2750372.
  • Sinn PL, Shah AJ, Donovan MD, McCray PB Jr. Viscoelastic gel formulations enhance airway epithelial gene transfer with viral vectors. Am J Respir Cell Mol Biol. 2005 May;32(5):404-10. PubMed PMID: 15695737.
  • Zhou M, Donovan MD. Intranasal Mucociliary Clearance of Bioadhesive Polymer Gels. International Journal of Pharmaceutics. 1996; 135:115-125.
  • Miller SC, Donovan MD. Effect of Poloxamer Gels on the Miotic Activity of Pilocarpin Nitrate in Rabbits. International Journal of Pharmaceutics. 1982; 12:147-152.