Center Affiliation and Expertise: Associate Center Member, Population Health Research Thematic Area
The primary research focus of the Chatterjee lab is to understand the molecular mechanisms underlying long-term memory loss in Alzheimer’s disease and related dementia (ADRD). His lab uses multifaceted state-of-the-art approaches such as single-nuclei (RNA+ATAC) multi-omics, spatial transcriptomics, native chromatin enrichment studies, proximity labeling, pharmacology, behavioral techniques, and AAV-based manipulation of transcription in the mouse brain. Using these tools, his goal is to understand the molecular mechanisms that go awry in neurodegeneration. His lab also employs humanized mouse models of ADRD, susceptible to amyloid or tauopathy to study the polychlorinated biphenyls (PCBs) induced neurotoxicity leading towards the risk for dementia (in collaboration with Dr. Hans Lehmler). His research on environmental health sciences focuses on assessing how human-relevant PCB mixtures alter the development and progression of ADRD-like phenotypes in animal models of ADRD.