The primary research focus of the Chatterjee lab is to understand the molecular mechanisms underlying long-term memory loss in Alzheimer’s disease and related dementia (ADRD). His lab uses multifaceted state-of-the-art approaches such as single-nuclei (RNA+ATAC) multi-omics, spatial transcriptomics, native chromatin enrichment studies, proximity labeling, pharmacology, behavioral techniques, and AAV-based manipulation of transcription in the mouse brain. Using these tools, his goal is to understand the molecular mechanisms that go awry in neurodegeneration. His lab also employs humanized mouse models of ADRD, susceptible to amyloid or tauopathy to study the polychlorinated biphenyls (PCBs) induced neurotoxicity leading towards the risk for dementia (in collaboration with Dr. Hans-Joachim Lehmler). His research on environmental health sciences focuses on assessing how human-relevant PCB mixtures alter the development and progression of ADRD-like phenotypes in animal models of ADRD.
Selected Publications:
- Basu B, Breese NM, Lombardi S, Wang H, Li X, Tiburcio D, Niemasz Z, Beyer SE, Dean LE, Marek RF, Toborek M, Lehmler H-J*, and Chatterjee S*. (2025) Spatial transcriptomic profiling uncovers the molecular effects of the neurotoxicant polychlorinated biphenyls (PCBs) in the brains of adult mice. Mol Psychiatry 31: 3257–3270.
- Bliese SR, Basu B, Beyer SE, Elsadany M, Michaelson JJ, Chatterjee S*. (2025) Single-cell resolution spatial transcriptomic signature of the retrosplenial cortex during memory consolidation. Mol Psychiatry. PMCID: PMC12645481
- Vanrobaeys Y., Mukherjee U., Langmack L., Beyer S.E, Bahl E., Lin LC., Michaelson JJ., Abel T*, and Chatterjee S*. (2023) Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation. Nature Communications. 14(1):6100. PMCID: PMC10541893
- Chatterjee S, Bahl E, Mukherjee U, Walsh EN, Shivarama Shetty M, Yan AL, Vanrobaeys Y, Lederman JD, Giese KP, Michaelson J and Abel T. (2022). Endoplasmic Reticulum Chaperone Genes Encode Effectors of Long-Term Memory. Science Advances 8(12): eabm6063. PMCID: PMC8942353
- Chatterjee S#, Angelakos# CC, Bahl E, Hawk JD, Gaine ME, Poplawski SG, Schneider-Anthony A, Yadav M, Porcari GS, Cassel JC, Giese KP, Michaelson JJ, Lyons LC, Boutillier AL and Abel T. (2020). The CBP KIX domain regulates long-term memory and circadian activity. BMC Biology; 18(1):155. PMCID: PMC7597000
- Gaine ME, Bahl E, Chatterjee S, Michaelson JJ, Abel T and Lyons LC (2021) Altered hippocampal transcriptome dynamics following sleep deprivation. Mol Brain;14(1):125. PMCID: PMC8361790
- Chatterjee S, Walsh E, Yan A, Giese KP, Safe S. and Abel T (2020) Pharmacological activation of Nr4A rescues age-associated memory decline. Neurobiology of Aging. 85:140-144. PMCID: PMC6917472
- Lyons LC, Chatterjee S, Vanrobaeys Y, Gaine ME and Abel T (2020) Translational Changes Induced by Acute Sleep Deprivation Uncovered by TRAP-Seq. Mol Brain 13(1):165. PMCID: PMC7713217
- Chatterjee S#, Cassel R#, Schneider-Anthony A#, Merienne K, Cosquer B, Tzeplaeff T, Sinha SH, Kumar M, Chaturbedy P, Eswaramoorthy M, Gras SL, Keime C, Bousiges O, Dutar P, Petsophonsakul P, Rampon C, Cassel JC, Buée L, Blum D, Kundu TK and Boutillier AL (2018) Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator. EMBO Mol Med; e8587. PMCID: PMC6220301
- Bridi MS, Hawk JD, Chatterjee S, Safe S, Abel T (2016) Pharmacological Activators of the NR4A Nuclear Receptors Enhance LTP in a CREB/CBP-Dependent Fashion. Neuropsychopharmacology; 42(6):1243-1253.