Environmental Health Sciences Research Center
University of Iowa College of Public Health
EHSRC Deputy Director, Dr. Peter Thorne, was featured in the Fall 2021 edition of the College of Public Health Magazine, InSight. He talked with CPH Communications Director, Dan McMillan, about the challenges of Climate Change. View a PDF of the interview by clicking on the image below.
EHSRC Director Dr. Hans-Joachim Lehmler was presented the 2021 John Doull Award at the annual Central States Society of Toxicology (CSSOT) Meeting, held virtually this year. As part of the award ceremony, Dr. Lehmler delivered a presentation titled, “PCB metabolism and neurotoxicity: highlights from a transatlantic journey.”
The John Doull award is presented each year by the CSSOT to honor the contributions of its members to the discipline of toxicology and the chapter. Each year there is a call for nominations prior to the Fall meeting. The winner of the award receives a medal.
Lehmler joined the University of Iowa in 2003 and currently leads a productive chemical toxicology laboratory linking the metabolism of current and emerging environmental contaminants, such as polychlorinated biphenyls (PCBs), pesticides, and environmental bisphenols, to their adverse health effects. He is internationally recognized for his studies on the disposition and toxicity of chiral PCBs. His current NIEHS-funded research employs novel animal models, including germ-free mice, transgenic animals, and population-based animal models, to characterize how the metabolism of chemical hazards affects toxic outcomes.
Dr. Lehmler serves as the Director of the NIEHS-funded Environmental Health Sciences Research Center (EHSRC) at the University of Iowa. In addition to his role as EHSRC Director, Dr. Lehmler is among the leadership team of the Exposure Science Facility and serves as the director of the Career Development Program of the EHSRC.
He also is the Deputy Director of the Iowa Superfund Research Program. Under this program, Dr. Lehmler leads a new Research Project investigating the neurotoxicity of polychlorinated biphenyls (PCBs) in adolescence. This Research Project brings together a multidisciplinary research team to study how local PCB metabolism in the brain affects neurotoxic outcomes in an adolescent rat model. Dr. Lehmler also leads the Synthesis Core of the Iowa Superfund Research Program and is a member of the leadership team of the Analytical Core.
He serves as Academic Editor of PLOSone and on NIH and DoD grant review panels. In addition, he is actively involved in the Central States Chapter of the Society of Toxicology and previously served as the Chapter’s secretary/treasurer for six years.
A recent publication by EHSRC member Dr. Ashutosh Mangalam’s group was featured as an E-Factor Paper of the Month NIEHS Environmental Factor Newsletter as a Paper of the Month! The E-Factor Papers of the Month highlight the highest impact and most innovative research funded by NIEHS. Congratulations to the authors!
Citation: Jensen SN, Cady NM, Shahi SK, Peterson SR, Gupta A, Gibson-Corley KN, Mangalam AK. 2021. Isoflavone diet ameliorates experimental autoimmune encephalomyelitis through modulation of gut bacteria depleted in patients with multiple sclerosis. Sci Adv 7(28):eabd4595.
As written in Environmental Factor Newsletter:
A new NIEHS-funded study in mice showed that a diet rich in the plant-based compound isoflavone may protect against multiple sclerosis (MS). The isoflavone diet was only protective when the mice had gut microbes capable of breaking down isoflavones. MS is a disease in which the immune system attacks nerves in the brain and spinal cord, resulting in muscle weakness and loss of balance or coordination.
The researchers fed mice with MS characteristics an isoflavone-rich or isoflavone-free diet for six weeks. They measured levels of inflammatory cells in the brain and spinal cord, a hallmark of MS, and characterized the makeup of the gut microbiome.
Mice fed an isoflavone-free diet had more severe disease, with greater numbers of inflammatory cells in the brain and spinal cord, than mice fed isoflavone-rich diets. Isoflavone-free mice lacked isoflavone-metabolizing gut bacteria, which were abundant in mice fed the plant-based compounds. When the researchers fed mice isoflavones but removed isoflavone-metabolizing bacteria, the diet no longer protected against MS-like symptoms. When the bacteria were restored, the protective effect of the isoflavone diet returned. Furthermore, the researchers showed that isoflavone-free mice given equol, a metabolite produced when gut bacteria breakdown isoflavone, were also protected against MS.
Results suggest that the development and severity of MS is influenced by both diet and the makeup of the gut microbiome. According to the authors, results can inform therapies for patients with MS.
The EHSRC Community Engagement Core is hosting two Science Cafes in September. Both events are focused on the issue of Climate Change and feature members of the EHSRC, Dr. Jerald Schnoor and Dr. Peter Thorne. See below for more info and to register! If you would like to request accessibility accommodations please email Jacqueline-Curnick@uiowa.edu
In-Person Event:
“Climate Change and the Looming COP26 Glasgow Meeting”
Dr. Jerald Schnoor
Wednesday, September 15th, 5-6 PM
On the lawn of the First St. Community Center
Mt. Vernon, IA
Virtual Event:
“Climageddon: Dire Predictions from the IPCC”
Dr. Peter Thorne
Tuesday, September 21st, 7-8 PM
Zoom
Peter Thorne, Deputy Director of the EHSRC, has been named to the Scientific Advisory Board (SAB) of the U.S. Environmental Protection Agency (EPA). The appointment was announced Aug. 2 by EPA Administrator Michael Regan.
“This highly qualified, diverse group of experts will ensure that EPA is receiving sound science-based advice to inform our work to protect people and the environment from pollution,” Regan said in a statement. “We worked expeditiously and deliberately to finalize the new Science Advisory Board, and now we can move forward knowing EPA’s work is guided by the most credible, independent expertise.”
Thorne joins 46 other members of the board, which provides scientific advice to the administrator, including reviewing the quality and relevance of information used by EPA or proposed as the basis for regulations, reviewing agency research programs and plans, and providing scientific advice as requested.
“I am excited to be serving as a science advisor to the EPA at a time when major decisions will be made regarding climate change mitigation and adaptation, the transition to sustainable energy systems, and the reduction of toxicant exposures in environmental justice communities.”
Thorne previously served on the SAB from 2011 to 2017, including a two-year term as SAB Chair from 2015 to 2017.
This article was originally posted here: https://www.public-health.uiowa.edu/news-items/thorne-appointed-to-epa-scientific-advisory-board/